Medicinal Plant

2013, v.4(02) 48-52

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Anti-oxidation Effects Polysaccharides from HERBA SCUTELLARIAE BARBATAE
Anti-oxidation Effects Polysaccharides from HERBA SCUTELLARIAE BARBATAE

Jie ZHAO;Shoutao GUAN;Shezong SUN;Hongmei ZHANG;Xinglin LIU;

摘要(Abstract):

[Objective] To research on the scavenging effects and anti-lipid peroxidation of HERBA SCUTELLARIAE BARBATAE polysaccharides. [Method] O-2· was produced by the autoxidation of pyrogallol; and ·OH was obtained by Fenton reaction. Scavenging effects of HERBA SCUTELLARIAE BARBATAE polysaccharides on ·OH and O-2· were researched. MDA contents were detected by thiobarbituric acid (TBA), which were the lipid peroxidation products of liver homogenates of the CCL4 liver injury mice and the healthy mice induced by Fe2+-H2O2. The anti-lipid peroxidation of HERBA SCUTELLARIAE BARBATAE polysaccharides was researched. [Result] HERBA SCUTELLARIAE BARBATAE polysaccharides had significant scavenging effects on O-2· and ·OH, showing dose-effect relationship. Polysaccharides could also restrict the autoxidation of liver homogenate of healthy mice and the lipid peroxidation induced by Fe2+-H2O2. Besides, administration groups of different dosages of HERBA SCUTELLARIAE BARBATAE polysaccharides could all significantly reduce the MDA content in CCL4-induced liver injury mice, and could significantly restrict the lipid peroxidation in vitro of liver homogenate of CCL4 liver injury mice. [Conclusion] HERBA SCUTELLARIAE BARBATAE polysaccharides had the functions of scavenging oxygen free radicals and anti-lipid peroxidation.

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作者(Author): Jie ZHAO;Shoutao GUAN;Shezong SUN;Hongmei ZHANG;Xinglin LIU;

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