Medicinal Plant

2015, v.6(Z1) 1-3+8

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The Antioxidant Activity of Scopolin from Solanum cathayanum to Nerve Cells
The Antioxidant Activity of Scopolin from Solanum cathayanum to Nerve Cells

Yushan KONG;Shaolan HUANG;Mingxia XIE;Yanhong XUE;Kun ZOU;Shiping LIU;

摘要(Abstract):

[Objective] To further detect the active components and functions of Solanum cathayanum,since previous research showed that it had relatively good antioxidant activity. [Methods] After extraction,isolation and structural identification,the antioxidant protection activity of scopolin from Solanum cathayanum to the damaged SH-SY5 Y cells was researched,which was induced by H2O2. [Results] Far from the toxicity range,scopolin showed similar antioxidant activity like positive control VE; and the LDH leakage rate reduced significantly,showing that scopolin reduced the membrane damage. Besides,0. 1 μmol / m L scopolin was helpful to enhance the contents of SOD and GSH. [Conclusions] Scopolin could be developed and used for the research on drugs for neurodegenerative diseases.

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基金项目(Foundation): Supported by the National Natural Science Foundation of China(31270389,31070313);; the Natural Science Foundation of Hubei Provincial Department of Education(D20121301)

作者(Author): Yushan KONG;Shaolan HUANG;Mingxia XIE;Yanhong XUE;Kun ZOU;Shiping LIU;

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