Medicinal Plant

2011, v.2(04) 20-22

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Study on Anti-oxidation and Antitumor Activities of Fermentations of Lepista sordida In Vitro
Study on Anti-oxidation and Antitumor Activities of Fermentations of Lepista sordida In Vitro

摘要(Abstract):

[Objective] To determine the in vitro anti-oxidation and antitumor activities of the fermentations from Lepista sordida.[Method] The secondary metabolites of L.sordida were extracted with different solvents,and the antioxidant and antitumor activities were determined by DPPH method and MTT assay,respectively.[Result] The ethyl acetone(EA)extracts of the solid fermentations exhibited the highest activity in DPPH radical inhibition assays,followed by the ethyl acetone(EA)extracts of the liquid fermentations.The ethyl acetone(EA)extracts of the liquid fermentations showed the highest antitumor activity and the IC50 value was about 50 μg/ml on the human cervix epitheloid carcinoma cell lines(Hela).The extracts of the mycelia also showed stronger antioxidative and antitumor activities.[Conclusion]The above-mentioned results provided new scientific basis for further study and exploitation of L.sordida.

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基金项目(Foundation): Supported by Science and Technology Planning of Guangdong Province(2005B33302005);; Natural Science Foundation of Guangdong Province(E05202480)

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