Medicinal Plant

2013, v.4(Z1) 22-23+26

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The Apoptosis of Human Tongue Carcinoma Induced by Plumbago zeylaniea L. and Exploration of Its Mechanism of Action
The Apoptosis of Human Tongue Carcinoma Induced by Plumbago zeylaniea L. and Exploration of Its Mechanism of Action

Zexiang DU;Farui BAI;

摘要(Abstract):

[Objective]To discuss the apoptosis of human tongue carcinoma induced by Plumbago zeylaniea L. and the impact of P. zeylaniea on telomerase activity. [Methods] The apoptosis of human tongue SqCa cultured in vitro was induced by the petroleum ether extracts from P. zeylaniea and then detected by flow cytometry. With Tca-8113 ad target cell,the in situ TRAP method was adopted to determine the telomerase activity. [Results] The apoptosis of SqCa Tca-8113 increased obviously when induced by the 8 mg / mL petroleum extracts from P. zeylaniea for 24 and 48 h; after 72 h,the telomerase activity declined significantly,and the inhibitive effect of telomerase activity increased with the concentration of P. zeylaniea concentration,showing a dose-dependent manner. [Conclusions] The petroleum ether extracts from Plumbago zeylaniea L. showed significant inhibitive effect on the proliferation of SqCa Tca-8113; and there is a possibility that P. zeylaniea fights against cancer by inhibiting telomerase activity and inducing SqCa apoptosis.

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作者(Author): Zexiang DU;Farui BAI;

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