Medicinal Plant

2011, v.2(09) 1-6

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Exploring Study on the Scavenging Activity on O_2~(·-) and Correlative Chemical Characteristic Fingerprint of Crataegus Leaves
Exploring Study on the Scavenging Activity on O_2~(·-) and Correlative Chemical Characteristic Fingerprint of Crataegus Leaves

摘要(Abstract):

[Objective] To study the relationship between HPLC fingerprint and scavenging activity on O·-2 of Crataegus leaves.[Method] Using O·-2 scavenging activity as evaluation index,the content of active ingredients in 5 species of Crataegus leaves was determined by HPLC for establishing mathematic models about the relationship between peak area and O·-2 scavenging activity(also named peak-efficacy fingerprint) .The HPLC fingerprint of Crataegus leaves was translated into bioactivity fingerprint including efficacy fingerprint and potency fingerprint with the helps of mathematics models,chemometrics,bioinformatics and computer programming and simulation etc.[Result] A new evaluative pattern,whose correlation coefficient between predicted value and practical value was 0.846(P<0.05) ,was successfully established for the quality of traditional Chinese medicine(TCM) .Besides,the predicted values of five species were all more than 70% of those in practical value.[Conclusion] This evaluative pattern is an all-around evaluative system,which includes not only chemical identification but also effective evaluation for TCM.This study that has made up for the deficiencies of current evaluative pattern for the quality of TCM would provide a new idea for modern study on TCM.

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基金项目(Foundation): Supported by National Natural Science Foundation of China(30472161);; Jiangxi Provincial Natural Science Foundation(0640163)

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