Medicinal Plant

2015, v.6(Z1) 44-46

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Experimental Study of Penthorum chinense Pursh on Mouse with Alcoholic Fatty Liver Disease
Experimental Study of Penthorum chinense Pursh on Mouse with Alcoholic Fatty Liver Disease

Xiangyu HU;Mei WEI;Yefei YUAN;Wenxin YANG;

摘要(Abstract):

[Objective] To explore the prevention effect of Penthorum chinense Pursh on alcoholic fatty liver disease in mouse. [Methods]Healthy Kunming SPF mouse were used in the test and with the modified modeling method established by Fan Jiangao et al.,mouse were fed with high fat diet and intragastric administration of alcohol at the dose of 3( BW) g / kg( 0. 1( BW) m L /10 g). While modeling,the Penthorum chinense Pursh extract was administrated for intervention,TPN was used as control. The general conditions of mouse were observed,the liver coefficient was detected and the blood was sampled from eyeballs for detection of serum TG,TC,ALT,AST and MDA.[Results]The alcoholic fatty liver disease occurred in mouse 3 weeks after modeling. The liver fat in Penthorum chinense Pursh extract group improved significantly and the serum TG,TC,ALT and AST in Penthorum chinense Pursh extract group decreased significantly compared with model group( p <0. 05,p < 0. 01). The serum MDA in Penthorum chinense Pursh extract group decreased compared with model group,but it was of no statistical significance.[Conclusions] Penthorum chinense Pursh had good effects on preventing and curing alcoholic fatty liver disease.

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基金项目(Foundation): United Youth Fund Program of Luzhou Medical College and Hospital(T.C.M)Affiliated to Luzhou Medical College(Lu Hospital Science[2013]12)

作者(Author): Xiangyu HU;Mei WEI;Yefei YUAN;Wenxin YANG;

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