Medicinal Plant

2014, v.5(09) 30-32+37

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Inhibitory Effects of Polyphenols from Pinus koraiensis Seed Scale on the Proliferation of Human Cancer Cells in Vitro
Inhibitory Effects of Polyphenols from Pinus koraiensis Seed Scale on the Proliferation of Human Cancer Cells in Vitro

Qun FU;Minghui XU;Xiaotang GAO;Zhenyu WANG;

摘要(Abstract):

[Objective] To research on the inhibitory effects of polyphenols from Pinus koraiensis seed scale on the proliferation of human cancer cells in vitro. [Methods] Polyphenols from Pinus koraiensis seed scale were prepared into extracting solutions at different concentrations. Suspension cultures of five tumor cells were processed,which were lung carcinoma cell A549,human bone marrow neuroblastoma cell SH-SY5 Y,human skin cancer cell A375,human hepatocarcinoma cell HepG-2 and human ovarian cancer cell SKOV3. Inhibitory rate of cell proliferation in vitro was detected by MTT method. [Results] P. koraiensis polyphenols had relatively good inhibitory effects on A549,showing certain correlation with time or concentration. The inhibitory rare was the optimal when the concentration of P. koraiensis polyphenols was0. 4 mg / mL. Under this concentration,the inhibitory rate of extracting solution of P. koraiensis polyphenols reached 55% on lung carcinoma cell A549. P. koraiensis polyphenols showed no significant inhibitory effects on SH-SY5 Y,A375,HepG 2 or SKOV3. [Conclusions] P. koraiensis polyphenols had inhibitory effects on lung carcinoma cells.

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基金项目(Foundation): Supported by the Surface Project of National Natural Science Foundation of China(C160131170510)

作者(Author): Qun FU;Minghui XU;Xiaotang GAO;Zhenyu WANG;

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