Medicinal Plant

2010, v.1(11) 28-29+32

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Effects of FRUCTUS SCHISANDRAE CHINENSIS on the Hepatic Antioxidant System and Trace Elements in Mice
Effects of FRUCTUS SCHISANDRAE CHINENSIS on the Hepatic Antioxidant System and Trace Elements in Mice

摘要(Abstract):

[Objective] To study the effects of FRUCTUS SCHISANDRAE CHINENSIS on the hepatic antioxidant system and trace elements in mice.[Methods] 40 male ICR mice were randomly divided into control group,low dose group,middle dose group and high dose group.Intragastric administration for 4 weeks,and then the content of reduced glutathione(GSH),malondialdehyde(MDA) and superoxide dismutase(SOD) in the hepatic tissue were determined.The hepatic tissue was digested by HNO3-HClO4 mixed acid,and the contents of Zn,Cu,Fe and Mn etc.four trace elements in it were determined by atomic absorption spectrometry.[Results] The contents of GSH and SOD in middle dose group were obvious higher than that in the control group(P<0.05).The contents of Cu,Fe and Mn in middle and high dose groups were obvious higher than that in the control group(P<0.05).[Conclusion] FRUCTUS SCHISANDRAE CHINENSIS could enhance the hepatic antioxidant ability of mice significantly through maintaining the balance of trace elements in liver.

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基金项目(Foundation): Supported by Eleventh Five-Year Scientific Research Project of Jilin Provincial Education Department (2008267)

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