Medicinal Plant

2012, v.3(04) 53-55

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Study on Acute Toxicity and Analgesic Effect of Total Flavonoids from FRUCTUS CANARII
Study on Acute Toxicity and Analgesic Effect of Total Flavonoids from FRUCTUS CANARII

摘要(Abstract):

[Objective] To observe the acute toxicity and analgesic effect of total flavonoids from FRUCTUS CANARII (TFFC). [Method] Mice in experimental medicine group were intragastrically administered TFFC, with the thickest concentration and the largest volume permitted. Mice in control group were administered the equal volume of solvent. The acute toxicity reaction of mice was observed in the successive 7 days. The analgesic effect of TFFC was observed by using the writhing assay and the hot-plate method in mice. [Result] After 7 days, all mice in the experimental medicine and control groups survived. The weight of mice in the two groups respectively increased by 28.0% and 25.0% (P>0.05), no acute toxicity was observed in both groups. The maximal tolerant dose (MTD) of TFFC by ig in mice was 11.46 g/kg, which was about 115 times of adult clinical daily dose. TFFC reduced the times of writhing induced by intraperitoneal injection of acetic acid in mice, improved pain threshold in hot-plate. [Conclusion] TFFC has little acute toxicity and good analgesic effect in mice.

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基金项目(Foundation): Supported by the Project of Science and Technology Bureau of Luzhou City([2008]23)

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