Medicinal Plant

2019, v.10(06) 90-93

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Study on Quality Standards of Children Antipyretic Lotion
Study on Quality Standards of Children Antipyretic Lotion

Suhong QIN;Jiahuan WEI;Guangyuan XIE;Zhenyuan WEI;Lilong YANG;Yuqing ZHOU;Min HUANG;

摘要(Abstract):

[Objectives] To establish suitable quality standards of children antipyretic lotion. [Methods] Qualitative identification was performed for Paederia scandens and Artemisia carvifolia in Children Antipyretic Lotion by thin-layer chromatography(TLC), and the content of paederosidic acid in children antipyretic lotion was determined by high performance liquid chromatography(HPLC). Besides, chromatographic column Feinigen XPeonyx C_(18)(250 mm×4.6 mm, 5 μm), mobile phase was used, gradient elution was carried out with acetonitrile-0.1% phosphoric acid aqueous solution, the detection wavelength was 236 nm, the flow rate was 1.0 mL/min, the column temperature was 30 ℃, and the injection volume was 10 μL. [Results] The thin-layer chromatography of P. scandens and A. carvifolia reference materials showed clear spots, good separation effect, strong specificity, and no interference in the limit control; paederosidic acid showed a good linear relationship in the range of 0.65-9.75 μg(R~2=0.999 6), the average sample recovery rate was 99.72%(RSD=2.52%). [Conclusions] The qualitative and quantitative methods established in this experiment are simple, reproducible, and the results are accurate and reliable, and can be applied as a quality control method for children antipyretic lotions.

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基金项目(Foundation): Supported by Open project of Guangxi Zhuang and Yao Pharmaceutical Engineering Technology Research Center(KJT1900105);; Key Research and Development Program of Department of Science and Technology of Guangxi Zhuang Autonomous Region(Guangxi Science and Technology AB19110003)

作者(Author): Suhong QIN;Jiahuan WEI;Guangyuan XIE;Zhenyuan WEI;Lilong YANG;Yuqing ZHOU;Min HUANG;

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