Medicinal Plant

2013, v.4(04) 59-63

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Effects of Curcumin on Proteome of HepG2 Cell
Effects of Curcumin on Proteome of HepG2 Cell

Dezhao LU;Ping'er WANG;Zhen YANG;Taoqi LIN;Lihua TANG;Yi LI;Xingde WO;

摘要(Abstract):

[Objective]To study the effect of curcumin on the proteome of HepG2 cells by using two-dimensional electrophoresis and mass spectrum.[Methods] The proteins from HepG2 cells and HepG2 cells treated with 30 μmol/L curcumin were separated with two-dimensional electrophoresis and the gels were scanned after silver staining.All images were analyzed by Image Master 6.0 software,and the different pro-teins were identified by mass spectrum.[Result] The expression of protein disulfide isomerase,replication protein A2,carnitine deficiency-associated gene and cyclin-dependent kinase inhibitor 2A increased in the HepG2 cell treated with 30 μmol/L curcumin,while the expression of PCNA,ER-60 protease,Ran binding protein 1,Stathmin 1/oncoprotein 18,Nm23 protein decreased.[Conclusion] Curcumin could in-hibit tumor cell growth,interfere cell cycle,promote apoptosis,inhibit tumor invasion and metastasis,and promote cell repair.In addition,the hypolipidemic and anti-atherosclerosis effects of curcumin may correlate with promotion of the transmembrane transport of fatty acids and maintain of cell membrane stability.

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基金项目(Foundation): Supported by National Nature Science Foundation of China (No.30873366,No.81102841)

作者(Author): Dezhao LU;Ping'er WANG;Zhen YANG;Taoqi LIN;Lihua TANG;Yi LI;Xingde WO;

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