Medicinal Plant

2012, v.3(11) 45-47+80

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Effects of Polygonum bistorla L.-413 on the Relaxant Mechanism of Isolated Thoracic Aortic Rings in Rats
Effects of Polygonum bistorla L.-413 on the Relaxant Mechanism of Isolated Thoracic Aortic Rings in Rats

LI Hong-liang;HE Fang-xing;SUN Li-bo;ZENG Jing;

摘要(Abstract):

[Objective] To research the effects of Polygonum bistorla L.-413 on the relaxant mechanism of isolated thoracic aortic rings in rats. [Method] Effects of P. bistorla-413 on the contraction of vascular smooth muscle induced by norepinephrine (NA) were studied under the Ca2+-contained and Ca2+-free bath solutions. Time-dependent manner of the relaxing effects of P. bistorla-413 was investigated. Effects of P. bistorla-413 on the contraction of vascular smooth muscle induced by 40 and 80 mmol/L KCl solutions were researched. [Result] P. bistorla-413 had relaxing effects on the contraction of vascular smooth muscle induced by NA in a concentration-dependent manner. P. bistorla-413 (100 μmol/L) reached the maximum relaxing effects at 30 min; P. bistorla-413 in Ca2+-free group had greater inhibitory effects on the contraction of vascular smooth muscle induced by NA than that in Ca2+-contained group. P. bistorla-413 had inhibitory effects on the contraction of vascular smooth muscle induced by 40 and 80 mmol/L KCl solutions. And the dose-response curve of the two obviously moved up. [Conclusion] P. bistorla-413 had relaxing effects on the vascular smooth muscle. And the action mechanism might be that P. bistorla-413 could promote the synthesis and release of NO, open the calcium-activated potassium channels, and inhibit calcium influx and inner calcium release of smooth muscle cell.

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基金项目(Foundation): Supported by the Natural Science Foundation of Jiangxi Province( 2011ZBAB214017);; the Science and Technology Plan Project of the Provincial Education Department of Jiangxi Province ( GJJ11206 );; the Science and Technology Plan Project of the Provincial Health Department of Jiangxi Province ( YB2009016 );; the Science and Technology Plan Project of Gannan Medical University ( YB201109)

作者(Author): LI Hong-liang;HE Fang-xing;SUN Li-bo;ZENG Jing;

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