Medicinal Plant

2014, v.5(02) 25-27

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Effect of MORINDAE OFFICINALIS Extract on the Behavior and Zymology of Senile Dementia Model Rats
Effect of MORINDAE OFFICINALIS Extract on the Behavior and Zymology of Senile Dementia Model Rats

Jiawei MIAO;Yuling FENG;Guoqi LAI;Shuangshuang JIA;Jing LI;

摘要(Abstract):

[Objective]To study the effect of MORINDAE OFFICINALIS extract on the behavior and zymology of senile dementia rat model. [Methods]Senile dementia rat model was prepared by intraperitoneal injection of D-galactose( 120 mg/kg) and sodium nitrite( 90 mg/kg) for 30 d. 60 rats were divided into 6 groups,normal control group,model group,nimodipine group,high-dosage group of aqueous extract of MORINDAE OFFICINALIS,medium-dosage group of aqueous extract of MORINDAE OFFICINALIS and low-dosage of aqueous extract of MORINDAE OFFICINALIS. The learning and memory ability was measured by rat step-down test. The activities of SOD,MDA and MAO-B were determined. The expression of MAO-B mRNA was determined by RT-PCR. [Results]After intraperitoneal injection of MORINDAE OFFICINALIS extract,the learning and memory abilities of model rats increased. The biochemical criterion of SOD,MDA and MAO-B was improved. The expression level of MAO-B mRNA decreased significantly. [Conclusions] Extract of MORINDAE OFFICINALIS could protect acute aging model rats at certain degree.

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基金项目(Foundation): The Medical Scientific Research Project of Chongqing Municipal Health Bureau(No:2012-096);; Major Project of Educational Reform of Chongqing Higher Education(No:132128,133309);; Science and Technology Planning Project of Wanzhou District(No:201203055)

作者(Author): Jiawei MIAO;Yuling FENG;Guoqi LAI;Shuangshuang JIA;Jing LI;

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