Medicinal Plant

2020, v.11(03) 6-10

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Research Progress in the Regulation of Tumor Cells and Tumor Stem Cells at Multiple Targets by Antrodia camphorata
Research Progress in the Regulation of Tumor Cells and Tumor Stem Cells at Multiple Targets by Antrodia camphorata

Qingfa CHEN;Yan XU;Xiaodong SHI;Chuanfei WEI;Haitao XIE;Ruxi LV;

摘要(Abstract):

Extensive in vitro and in vivo research reveals multiple intracellular molecular targets of Antrodia camphorata, and these targets affect growth, apoptosis, angiogenesis, invasion and metastasis of cells. These targets include tumor suppressor, cell cycle regulator, transcription factor, angiogenesis and metastasis factor, apoptosis and survival regulator, etc. Additionally, more and more attention has been paid to the molecular mechanism of A. camphorata on the regulation of tumor stem cells. Meanwhile, there is evidence that the immunoregulation of A. camphorata is enhanced, which may lead cell cycle arrest or apoptosis. In this paper, molecular mechanism of tumor cells and tumor stem cells regulated at multiple targets by A. camphorata in vitro and in vivo in the past decade is summarized.

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基金项目(Foundation): Supported by Shandong Medical and Health Development Plan (2018WS423)

作者(Author): Qingfa CHEN;Yan XU;Xiaodong SHI;Chuanfei WEI;Haitao XIE;Ruxi LV;

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