Medicinal Plant

2010, v.1(10) 52-54

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The Effect of Grifola frondosa Polysaccharide on Immune Function in Mice
The Effect of Grifola frondosa Polysaccharide on Immune Function in Mice

摘要(Abstract):

[Objective] The research aimed to discuss the effects of Grifola frondosa polysaccharide on immune function in mice. [Method] The 30 healthy Kunming mice were randomly divided into three groups of 10 each: control group, low-dose group and high-dose group. Low-dose group and high-dose group mice were respectively fed with low or high doses of Grifola frondosa polysaccharides (300 or 400 mg/kg body weight). Control group mice were fed with distilled water. Mice of each group were allowed to feed on their dose once a day for 15 successive days to study the effect of Grifola frondosa polysaccharide on immune organ weight and blood biochemical indexes.[Result] The results showed that the thymus index in low-dose group was significantly lower than that in control group (P<0.05), and spleen index in low-dose group and high-dose group was very significantly and significantly higher than that in control group (P<0.01, P<0.05), respectively. The serum total protein and the serum globulin levels in low-dose group were significantly or very significantly higher than that in control group (P<0.05, P<0.01). The serum total cholesterols level in low-dose group was significantly lower than that in control group (P<0.05). The serum IgG in low-dose group was significantly higher than that in control group (P<0.05). [Conclusion] The results indicated that the Grifola frondosa polysaccharides in low-dose group could increase the spleen weight and serum antibody content and reduce total cholesterol level, which had a significant effect on enhancing immune function and reducing blood lipids in mice.

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基金项目(Foundation): Supported by "Hong Kong Ming Yuan Fund Research Grants" (No:314-140549)

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