Medicinal Plant

2016, v.7(Z2) 16-18

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

Studies on Anti-inflammatory Effects and Mechanism of Phellodendri Chinensis Cortex
Studies on Anti-inflammatory Effects and Mechanism of Phellodendri Chinensis Cortex

Lilan OU;Xin YU;Chun ZHANG;Ye ZHU;

摘要(Abstract):

[Objective] To observe the anti-inflammatory effects of alcohol extract of Phellodendri Chinensis Corte and explore its mechanism.[Method]ICR mice were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g/kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the mice orally once a day for 15 days. After30 min of the last administration,its anti-inflammatory effect was observed by the method of acetic acid-induced permeability accentuation. SD rats were divided into 5 groups randomly,namely the model group,dexameathone group( 0. 01 g / kg),alcohol extraction of Phellodendri Chinensis Corte groups( 9. 0,4. 5 and 3. 0 g / kg). Each drug was administrated to the rats orally once a day for 15 days. After 30 min of the last administration,the rat model of carrageenan-induced acute pleurisy was also selected to observe the anti-inflamatory effect. The anti-inflammatory mechanism was investigated by detecting the contents of prostaglandins( PGE_2),tumor necrosis factor-alpha( TNF-α),and interleukin-1β( IL-1β) in the exudates,and the contents of TNF-α,IL-1β,and malondialdehyde( MDA) in the lung tissue were also detected.[Result]Compared with the model group,the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5 g/kg) had significant inhibitory effects on the acetic acid-induced permeability accentuation in the mice,while the alcohol extract of Phellodendri Chinensis Corte groups( 9. 0 and 4. 5g / kg) significantly reduced the levels of PGE_2,TNF-α and IL-1β in the exudates( P <0. 05),while the high-dose alcohol extract of Phellodendri Chinensis Corte group( 9. 0 g / kg) also reduced the contents of TNF-α,IL-1β and MDA in the lung tissue of the carrageenan treated rats( P < 0. 01),and the moderate-dose alcohol extract of Phellodendri Chinensis Corte group( 4. 5 g / kg) decreased the content of IL-1β in the lung tissue( P < 0. 01). [Conclusion]The alcohol extraction of Phellodendri Chinensis Corte possesses significant anti-inflammatory effects,which can be related to the inhibition of generation of the inflammatory mediators and its antioxidation.

关键词(KeyWords):

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): Lilan OU;Xin YU;Chun ZHANG;Ye ZHU;

Email:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享