Medicinal Plant

2010, v.1(10) 29-30+32

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Effect of SPICA PRUNELLAE Decoction on the Contraction of Frog Heart in Vitro
Effect of SPICA PRUNELLAE Decoction on the Contraction of Frog Heart in Vitro

摘要(Abstract):

[Objective] To study the effects of SPICA PRUNELLAE water extract on the systolic function of frog heart in vitro.[Method] The effects of different concentrations of SPICA PRUNELLAE extract on the isolated frog heart were observed by perfusion method through BL-420F biological experimental system.[Result] The myocardial tension and the heart rate of the isolated frog heart can be enhanced by lower concentration of SPICA PRUNELLAE decoction(0.000 01-0.000 08 g/ml)(P<0.01),while negatively affected by high concentration of SPICA PRUNELLAE decoction(0.01-0.08 g/ml);cardiac arrest even took place when the concentration of SPICA PRUNELLAE decoction up to 0.1 g/ml(P<0.01).[Conclusion] It was concluded that SPICA PRUNELLAE has bidirectional adjust effect on the heart.

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