Medicinal Plant

2012, v.3(08) 60-63

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Acute Toxicity of Reinwardtia trigyna Water Extracts to Mice Liver and Kidney Functions and Blood Cell Count
Acute Toxicity of Reinwardtia trigyna Water Extracts to Mice Liver and Kidney Functions and Blood Cell Count

摘要(Abstract):

[Objective]To detect the acute toxicity of R.trigyna water extracts to mice,and to detect the toxicity of R.trigyna water extracts in short term.[Method]After given the R.trigyna by gavage,mice were observed for 10 d and the physical signs and activity situation were recorded.Liver and kidney functions and blood routine were detected.[Result]Effects of R.trigyna water extracts on the mice leukocyte were the greatest,but the two showed no linear relationship.The low and high doses had little effects but the middle dose had significant effects.R.trigyna water extracts had few effects on lymphocyt and monocyte,had great effects on neutrophil,had relatively small effects on erythrocyte except group D, and had no significant effects on hemoglobin.R.trigyna had no significant effects on the physical signs and activity condition of mice,which reduced the leukocyte and neutrophil in blood and led to the decrease of immune function.High dose caused the liver toxicity and had no significant effects on kidney.[Conclusion]R.trigyna water extracts had certain toxicological effects on mice,and high dose showed relatively great toxicity.

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基金项目(Foundation): Supported by the Cultivation Plan Project for the Distinguished Bachelor Thesis of Sichuan Agricultural University

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