Medicinal Plant

2011, v.2(12) 12-13+16

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Protective Effect of Rubus delavayi Franch on Acute Liver Injury in Mice
Protective Effect of Rubus delavayi Franch on Acute Liver Injury in Mice

摘要(Abstract):

[Objective]To study the protective effect of Rubus delavayi Franch on acute liver injury induced in mice by tetrachloromethane (CCl4) . [Methods]The model of acute liver injury induced by CCl4 was treated with ethanol extract of Rubus delavayi Franch throughout the experiment. the activity of alanine aminotransferase ( ALT) ,aspartate aminotransferase (AST) in serum ,the content of malondialdehyde (MDA) ,and glutathione (GSH) in liver were detected. [Results]Rubus delavayi Franch significantly reduced the activity of AST,ALT and the content of MDA(P <0.05) , while significantly increased the content of GSH (P <0. 05) . [Conclusion]Rubus delavayi Franch has the protective effect on acute liver injury induced by CCl4 ,which has good dose-effect relationship,while the mechanism needs to be further studied.

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