Medicinal Plant

2013, v.4(Z1) 52-54

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Establishment of Diabetic Foot Ulcer Model in Guangxi Bama Mini-pig
Establishment of Diabetic Foot Ulcer Model in Guangxi Bama Mini-pig

Qin LUO;Xiaoqun DUAN;Shaoye XU;Shaorui SONG;Hui SHEN;

摘要(Abstract):

[Objective]To establish a new simple and steady diabetic foot ulcer model for the clinical and basic study of diabetic skin ulcer. [Methods]Five pigs were randomly divided into control group( n =2) and experiment group( n =3). Pigs in control group were fed with basal diet while those in experimental group were fed with high-fat and high-sucrose diet. When the model was established,the skin ulcer was burned on back,neck and limbs of the pigs after anesthesia. The wounds were examined by histological analysis and the areas of wounds were measured at different time points. [Results]Diabetic models were successfully established,there were no significant differences in morphology of ulcers in both groups. Weights of pigs in both groups increased and the food and water intake changed a little. Ulcers in both groups stayed unhealed after 4 weeks. After 4 weeks,the ulcers were examined by histological analysis. The structure of the epidermis and dermis were disappeared along with cell degeneration. The histopathological changes of subcutaneous fatty tissue and underlying muscle tissue were characterized by degeneration. [Conclusions] The animal model can simulate clinical diabetic skin ulcer and the method of establishing such model is easy and reliable.

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基金项目(Foundation): Guangxi Science and Technology Development Project(Project Number:Ke'nen 10100027-4)

作者(Author): Qin LUO;Xiaoqun DUAN;Shaoye XU;Shaorui SONG;Hui SHEN;

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