Medicinal Plant

2011, v.2(09) 9-12

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Study on the Synthesis and Antifungal Activity of Chalcone Analogues
Study on the Synthesis and Antifungal Activity of Chalcone Analogues

摘要(Abstract):

[Objective] To synthesize chalcone analogues and study their antifungal activity so as to find high-efficient and safe compounds with antifungal activity.[Method] With benzoyl chloride compounds and amines as the materials,16 chalcone analogues were designed and synthesized through the aminolysis reaction of acyl chloride,and their molecular structures were determined by IR and 1H NMR.[Result] The chalcone analogues had certain antifungal activity.The antifungal rate of 100 mg/L compound A2(2-chloro-N-phenyl benzamide) against Rhizoctonia solani and Sclerotiua sclerotiorum reached 90.27% and 92.56%,respectively.[Conclusion] Product A2 was an analogue of the natural product chalcone that could naturally degrade without causing environmental pollution.What's more,its chemical structure was simple and easy to prepare.Using A2 as a lead compound,new high-efficient and low-toxic antifungal agents which were safe to the non-target organisms could be developed through optimizing its chemical structure and studying the relationship between structure and activity.

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基金项目(Foundation): Supported by the Organic Chemistry Key Discipline of Xihua University

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