Medicinal Plant

2013, v.4(10) 24-26+29

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Dosage-effect Relationship of Astragalus-Salvia's Effective Components in E-cadherin Expression of UUO Rat
Dosage-effect Relationship of Astragalus-Salvia's Effective Components in E-cadherin Expression of UUO Rat

Jun LI;Xiaomin YANG;Xu FU;Dong WANG;Ping ZHOU;


[Objective]By the observation of dosage-effect relationship of Astragalus and Salvia's effective components in E-cadherin Expression of UUO rat,an analysis of the effect on renal tubular epithelial cells was made and pathological changes of renal tubule interstitial fibrosis under different concentrations of Astragalus-Salvia drugs were observed and compared.[Methods]Forty SD rats were randomly classified into five groups:normal group,model group,Astragalus-Salvia drug granules compatibility(1∶1)low dosage group(hereinafter referred to as the low dosage group),middle dosage group and high dosage group.Double distilled water gavage was given to normal group and model group,rather 14 d therapy of relevant drug gavage to other groups to test serum creatinine(Scr),blood urea nitrogen(BUN)and 24 h urine protein content and to observe the renal pathology and collagen deposition with light microscope.The immunohistochemical method was used to detect E-cadherin changes in renal tissue.[Results]The renal function,pathological damage,collagen deposition and immunohistochemical results of different groups of kidney was the most obvious in module group and the least in high dosage group.[Conclusions]Astragalus-Salvia drugs have a certain protective effect on renal function of UUO rats and renal tubular function.Furthermore,with the dosage increased,the effect is more obvious,whose mechanism may be correlated with the gradual enhancement of E-cadherin expression;there exists dosage-effect relationship of Astragalus-Salvia's effective components in E-cadherin expression of UUO rats,with the most obvious effect of high dosage group.




基金项目(Foundation): Supported by National Nature Science Foundation Project of China(30960490);; Social Research Project of Guizhou Province(SY[2009]3078);; Governor Fund Projects of Guizhou Province(2010)69

作者(Author): Jun LI;Xiaomin YANG;Xu FU;Dong WANG;Ping ZHOU;