Medicinal Plant

2011, v.2(12) 1-3

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Promoting of Animal Gastrointestinal Motility by “Qingpi San” Emulsion
Promoting of Animal Gastrointestinal Motility by "Qingpi San" Emulsion

摘要(Abstract):

[Objective]To investigate the effects of " Qingpi San" emulsion on the gastrointestinal motility of animals with gastroparesis,and to discuss its action mechanism. [Method]Animal model with gastrointestinal motility disorder was constructed and " Qingpi San" emulsion was given by gavage. Then,the remaining rate of substance in mice stomach was calculated,as well as the intestinal movement percentage of mixture of Arabian gel and active charcoal powder. MTL (motilin) levels in the plasma,gastric and intestinal homogenate of rats were measured,as well as the MTL distribution change in the jejunum and gastric antrum of rats. [Result] " Qingpi San" emulsion could effectively reduce the remaining rate of substance in stomach of normal mice,significantly enhance the intestinal propulsive movements percentage of mice,significantly improve the MTL levels in the plasma,gastric and intestinal homogenate in mole animals with gastrointestinal motility disorder,as well as the expression of MTL positive material in their gastric antrum and jejunum. [Conclusion]The promoting of gastrointestinal motility of the tested animal by " Qingpi San" emulsion was related to the increase of MTL level in their plasma,gastric and intestinal homogenate as well as the distribution change of MTL cells in their gastrointestinal tract.

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