Medicinal Plant

2019, v.10(06) 20-23

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Stability of Sanguinarine and Chelerythrine in Macleaya cordata (Willd.) R. Br.
Stability of Sanguinarine and Chelerythrine in Macleaya cordata (Willd.) R. Br.

Chunmei LI;Xu CHEN;Wenlan LI;Bingmei LIU;Li WANG;Yubin JI;

摘要(Abstract):

[Objectives] To explore the stability of sanguinarine and chelerythrine in Macleaya cordata(Willd.) R. Br. [Methods] The solubility and stability of sanguinarine and chelerythrine in seven solvents were measured by HPLC. Besides, the effects of water quality, light source, oxidant, temperature, and pH on stability were investigated. [Results] The solubility and stability of sanguinarine and chelerythrine in methanol and ethanol are good; the stability of sanguinarine and chelerythrine in distilled water and rainwater is not affected by light and is very stable, but they are unstable in tap water whether they are protected from light or not; oxidants have a great influence on the stability of sanguinarine and chelerythrine; sanguinarine and chelerythrine are stable at room temperature lower than 54 ℃; sanguinarine is stable in pH 2.5-7.0, while chelerythrine is stable in pH 2.5-8.0. [Conclusions] The good stability of sanguinarine and chelerythrine under specific conditions shows that they have broad development prospects and value.

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基金项目(Foundation): Supported by Post-doctoral Foundation Project of Heilongjiang Province(LBHZ16094);; Special Research Fund Project for Scientific and Technological Innovation Talents in Harbin City(2017RAQXJ115);; Doctoral Starting up Project of Harbin University of Commerce(2019DS114)

作者(Author): Chunmei LI;Xu CHEN;Wenlan LI;Bingmei LIU;Li WANG;Yubin JI;

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