Medicinal Plant

2020, v.11(03) 70-73

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Effects of Dachengqi Decoctions Made from Raw Rhubarb and Vinegar-processed Rhubarb on Levels of Endotoxin, NO and TNF-α in Serum
Effects of Dachengqi Decoctions Made from Raw Rhubarb and Vinegar-processed Rhubarb on Levels of Endotoxin, NO and TNF-α in Serum

Wen ZHONG;Zujie QIN;Jiangcun WEI;Zhen XIE;Xiumei MA;Xianyi SHI;Fengxian ZHAO;Qian HAN;

摘要(Abstract):

[Objectives] The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin, NO and TNF-α levels were investigated. [Methods] Total 105 mice were randomly divided into Dachengqi decoction made from raw rhubarb groups(6, 10 g/kg), Dachengqi decoction made from vinegar-processed rhubarb groups(6, 10 g/kg), positive control group, blank control group and model group. After administration at a dose of 20 mL/kg, the levels of endotoxin, NO and TNF-α in serum were determined. The effects of Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb on serum endotoxin, NO and TNF-α levels in mice were compared. [Results] Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb both increased the NO level and reduced the endotoxin and TNF-α levels in serum of ABP mice. [Conclusions] Dachengqi decoctions made from raw rhubarb and vinegar-processed rhubarb have different effects on endotoxin, NO and TNF-α contents. These changes correspond to the effects of Dachengqi Decoctions made from raw rhubarb and vinegar-processed rhubarb. The change in the content of rhubarb anthraquinones has a certain effect on the efficacy of Dachengqi decoction.

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基金项目(Foundation): Supported by National Natural Science Foundation of China(No.81360524);; Youth Foundation of Guangxi University of Chinese Medicine(No.2019QN036);; Project for Improving Basic Scientific Research Ability of Young and Middle-aged Teachers in Colleges and Universities of Guangxi in 2019(No.2019KY0341);; Traditional Chinese Medicine Scientific Research Laboratory(Grade III) of National Administration of Traditional Chinese Medicine:Laboratory of Chinese(Zhuang) Medicine Chemical and Quality Analysis(Guo Zhong Yi Yao Fa 2009[21])

作者(Author): Wen ZHONG;Zujie QIN;Jiangcun WEI;Zhen XIE;Xiumei MA;Xianyi SHI;Fengxian ZHAO;Qian HAN;

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