Medicinal Plant

2012, v.3(11) 51-53

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Effect of Volatile Oil from Bupleurum chinense DC. on Energy Metabolism of the Liver in Rats
Effect of Volatile Oil from Bupleurum chinense DC. on Energy Metabolism of the Liver in Rats

SUN Rong;YANG Qian;

摘要(Abstract):

[Objective] To explore the energy mechanism of volatile oil from Bupleurum chinense DC. for hepatotoxic injury. [Method] Volatile oil from B. chinense at the dose of 0.19, 0.28 and 0.42 ml/kg was given to rats by intragastric administration for 15 d continually. The changes in respiratory function, ATP content and ATPases activity of hepatic mitochondrion were detected. [Result] Compared with normal control group, the respiratory control rate (RCR) and phosphorus/oxygen rate (P/O) reduced from (1.76±0.28)% and (1.28±0.38) to (0.76±0.12)% and (0.71±0.21) in volatile oil from B. chinense 0.42 ml/kg group respectively, and the respiratory oxygen uptake were reduced from (2. 82±0. 64) to (1.04±0.23) mol/min·g. ATP content was reduced from (1.00±0.18) to (0.72±0.13) μmol per gram of protein, and activities of Na+-K+-ATPase, Mg2+-ATPase and Ca2+-ATPase from (0.94±0.14), (0.95±0.14) and (0.97±0.16) mmol/h·g protein to (0.53±0.08), (0.67±0.10) and (0. 65±0.11) mmol/h·g protein, respectively. Compared with normal control group, RCR, P/O, respiratory oxygen uptake, ATP content and ATPases activities in volatile oil from B. chinense 0.28 and 0.19 ml/kg groups were also significantly reduced.[Conclusion] Volatile oil from B. chinense can cause hepatotoxicity in rats by inhibiting function of hepatic mitochondrion and influencing the energy metabolism of the liver.

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基金项目(Foundation): Supported by National Natural Science Foundation of China( 30672649,81073148);; Shandong Provincial High Technology Research and Development Program ( 2007GG2NS02073 );; Shandong Provincial Introducing Foreign Intelligence Program ( L20083700336);; Key Programs of Natural Science Foundation of Shandong Province ( 2011ZRB14333)

作者(Author): SUN Rong;YANG Qian;

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